rdf:type |
|
lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0008972,
umls-concept:C0008976,
umls-concept:C0025098,
umls-concept:C0034656,
umls-concept:C0035020,
umls-concept:C0048306,
umls-concept:C0201734,
umls-concept:C0205210,
umls-concept:C0220825,
umls-concept:C0337810,
umls-concept:C0521425,
umls-concept:C1257890,
umls-concept:C1274040,
umls-concept:C1516213
|
pubmed:issue |
7
|
pubmed:dateCreated |
1997-10-20
|
pubmed:abstractText |
In postmenopausal breast cancer (BC) patients, tamoxifen (TAM) is frequently used in first-line therapy, and for those relapsing under TAM, aromatase inhibitors would be the drug of choice. Formestane, a new aromatase inhibitor, has been demonstrated to be as effective as TAM in first-line therapy. This trial was carried out to investigate the pharmacokinetics and antitumor activity of two formestane doses in BC patients at first relapse, as well as their effects on estrogen levels, evaluated by means of a new analytical method.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0923-7534
|
pubmed:author |
pubmed-author:AmichettiMM,
pubmed-author:AttiliAA,
pubmed-author:BajettaEE,
pubmed-author:Bari?LL,
pubmed-author:BichisaoEE,
pubmed-author:BolelliG FGF,
pubmed-author:BombardieriEE,
pubmed-author:BuzzoniRR,
pubmed-author:ComellaGG,
pubmed-author:D'AprileMM,
pubmed-author:FerrariLL,
pubmed-author:JirilloAA,
pubmed-author:MartinettiAA,
pubmed-author:NoberascoCC,
pubmed-author:SchieppatiGG,
pubmed-author:ZilemboNN
|
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
649-54
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:9296217-Adult,
pubmed-meshheading:9296217-Aged,
pubmed-meshheading:9296217-Aged, 80 and over,
pubmed-meshheading:9296217-Androstenedione,
pubmed-meshheading:9296217-Antineoplastic Agents,
pubmed-meshheading:9296217-Aromatase Inhibitors,
pubmed-meshheading:9296217-Breast Neoplasms,
pubmed-meshheading:9296217-Estradiol,
pubmed-meshheading:9296217-Estrone,
pubmed-meshheading:9296217-Female,
pubmed-meshheading:9296217-Humans,
pubmed-meshheading:9296217-Injections, Intramuscular,
pubmed-meshheading:9296217-Middle Aged,
pubmed-meshheading:9296217-Postmenopause,
pubmed-meshheading:9296217-Survival Analysis,
pubmed-meshheading:9296217-Treatment Outcome
|
pubmed:year |
1997
|
pubmed:articleTitle |
A multicentre, randomized, pharmacokinetic, endocrine and clinical study to evaluate formestane in breast cancer patients at first relapse: endocrine and clinical results. The Italian Trials in Medical Oncology (I.T.M.O.) group.
|
pubmed:affiliation |
Division of Medical Oncology B, Instituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Multicenter Study
|