| pubmed-article:9295299 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9295299 | lifeskim:mentions | umls-concept:C0054450 | lld:lifeskim |
| pubmed-article:9295299 | lifeskim:mentions | umls-concept:C0040691 | lld:lifeskim |
| pubmed-article:9295299 | lifeskim:mentions | umls-concept:C1413103 | lld:lifeskim |
| pubmed-article:9295299 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9295299 | lifeskim:mentions | umls-concept:C0173545 | lld:lifeskim |
| pubmed-article:9295299 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:9295299 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
| pubmed-article:9295299 | pubmed:abstractText | Transforming growth factor beta (TGF-beta) is a pluripotent peptide hormone that regulates various cellular activities, including growth, differentiation, and extracellular matrix protein gene expression. We previously showed that TGF-beta induces the transcriptional activation domain (TAD) of CTF-1, the prototypic member of the CTF/NF-I family of transcription factors. This induction correlates with the proposed role of CTF/NF-I binding sites in collagen gene induction by TGF-beta. However, the mechanisms of TGF-beta signal transduction remain poorly understood. Here, we analyzed the role of free calcium signaling in the induction of CTF-1 transcriptional activity by TGF-beta. We found that TGF-beta stimulates calcium influx and mediates an increase of the cytoplasmic calcium concentration in NIH3T3 cells. TGF-beta induction of CTF-1 is inhibited in cells pretreated with thapsigargin, which depletes the endoplasmic reticulum calcium stores, thus further arguing for the potential relevance of calcium mobilization in TGF-beta action. Consistent with this possibility, expression of a constitutively active form of the calcium/calmodulin-dependent phosphatase calcineurin or of the calcium/calmodulin-dependent kinase IV (DeltaCaMKIV) specifically induces the CTF-1 TAD and the endogenous mouse CTF/NF-I proteins. Both calcineurin- and DeltaCaMKIV-mediated induction require the previously identified TGF-beta-responsive domain of CTF-1. The immunosuppressants cyclosporin A and FK506 abolish calcineurin-mediated induction of CTF-1 activity. However, TGF-beta still induces the CTF-1 TAD in cells treated with these compounds or in cells overexpressing both calcineurin and DeltaCaMKIV, suggesting that other calcium-sensitive enzymes might mediate TGF-beta action. These results identify CTF/NF-I as a novel calcium signaling pathway-responsive transcription factor and further suggest multiple molecular mechanisms for the induction of CTF/NF-I transcriptional activity by growth factors. | lld:pubmed |
| pubmed-article:9295299 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9295299 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9295299 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9295299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9295299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9295299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9295299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9295299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9295299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9295299 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9295299 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9295299 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9295299 | pubmed:author | pubmed-author:MermodNN | lld:pubmed |
| pubmed-article:9295299 | pubmed:author | pubmed-author:DusserreYY | lld:pubmed |
| pubmed-article:9295299 | pubmed:author | pubmed-author:RüeggUU | lld:pubmed |
| pubmed-article:9295299 | pubmed:author | pubmed-author:Alevizopoulos... | lld:pubmed |
| pubmed-article:9295299 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9295299 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:9295299 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:9295299 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9295299 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9295299 | pubmed:pagination | 23597-605 | lld:pubmed |
| pubmed-article:9295299 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9295299 | pubmed:meshHeading | pubmed-meshheading:9295299-... | lld:pubmed |
| pubmed-article:9295299 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9295299 | pubmed:articleTitle | Regulation of the transforming growth factor beta-responsive transcription factor CTF-1 by calcineurin and calcium/calmodulin-dependent protein kinase IV. | lld:pubmed |
| pubmed-article:9295299 | pubmed:affiliation | Laboratory of Molecular Biotechnology, Center of Biotechnology UNIL-EPFL, DC-IGC, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. | lld:pubmed |
| pubmed-article:9295299 | pubmed:publicationType | Journal Article | lld:pubmed |
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