Linked Life Data

9295110

Source:http://linkedlifedata.com/resource/pubmed/id/9295110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1997-10-23
pubmed:abstractText
Participation of the neuronal nicotinic receptor subunit alpha6 in a physiologically relevant receptor has yet to be demonstrated, but its high degree of expression in catecholaminergic nuclei has attracted considerable interest. To investigate the pattern of expression of the alpha6 protein, a subunit specific antibody against the alpha6 subunit was used to immunohistochemically label sections of the adult rat brain. Alpha6 immunoreactivity was found to be present in the substantia nigra, the ventral tegmental area, the locus coeruleus and the medial habenula, and double-labeling for tyrosine hydroxylase demonstrated that the alpha6 protein is present on dopaminergic neurons of the midbrain. A possible role for the alpha6 subunit in nicotinic modulation of dopaminergic transmission is therefore proposed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2739-42
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Immunohistochemical localization of the nicotinic acetylcholine receptor subunit alpha6 to dopaminergic neurons in the substantia nigra and ventral tegmental area.
pubmed:affiliation
Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.