Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1997-9-24
|
| pubmed:abstractText |
Disturbances in the orbital prefrontal cortex and its ventral striatal target fields have been identified in neuroimaging studies of obsessive-compulsive disorder (OCD). In animal models and studies of patients with lesions to this brain circuitry, a selective disturbance in the ability to suppress responses to irrelevant stimuli has been demonstrated. Such a deficit in response suppression might underlie the apparent inhibitory deficit suggested by the symptoms of OCD. To date, little direct evidence of such a deficit has been reported. Further, although OCD commonly emerges during childhood or adolescence, few studies have examined psychotropic-naive pediatric patients near the onset of illness to find the possible role of atypical developmental processes in this disorder.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0003-990X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
831-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9294374-Adolescent,
pubmed-meshheading:9294374-Age Factors,
pubmed-meshheading:9294374-Child,
pubmed-meshheading:9294374-Corpus Striatum,
pubmed-meshheading:9294374-Eye Movements,
pubmed-meshheading:9294374-Female,
pubmed-meshheading:9294374-Functional Laterality,
pubmed-meshheading:9294374-Humans,
pubmed-meshheading:9294374-Male,
pubmed-meshheading:9294374-Neural Pathways,
pubmed-meshheading:9294374-Neuropsychological Tests,
pubmed-meshheading:9294374-Obsessive-Compulsive Disorder,
pubmed-meshheading:9294374-Personality Inventory,
pubmed-meshheading:9294374-Prefrontal Cortex,
pubmed-meshheading:9294374-Psychiatric Status Rating Scales,
pubmed-meshheading:9294374-Reaction Time,
pubmed-meshheading:9294374-Saccades,
pubmed-meshheading:9294374-Severity of Illness Index
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Oculomotor response inhibition abnormalities in pediatric obsessive-compulsive disorder.
|
| pubmed:affiliation |
Department of Psychiatry, University of Pittsburgh Medical Center, Pa., USA. Drosen@med.wayne.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|