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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-10-22
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pubmed:abstractText |
In vivo models for human B cell precursor ALL have been established by transplanting human leukemic cells onto immune-deficient SCID mice. High risk and relapsed leukemias engraft very well in these mice, however, good prognosis pediatric ALL often grow poorly if at all. Recently a new, even more immune-deficient mouse strain has been bred by crossing the scid mutation onto the NOD mouse background. As these NOD-SCID mice have been shown to be better recipients for human myeloid cells the goal of this study was to test these mice as hosts for human acute lymphoblastic leukemia cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-8630
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
209
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-85
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9293448-Adult,
pubmed-meshheading:9293448-Animals,
pubmed-meshheading:9293448-Bone Marrow,
pubmed-meshheading:9293448-Bone Marrow Transplantation,
pubmed-meshheading:9293448-Child,
pubmed-meshheading:9293448-DNA, Neoplasm,
pubmed-meshheading:9293448-Flow Cytometry,
pubmed-meshheading:9293448-Gene Expression Regulation, Leukemic,
pubmed-meshheading:9293448-Graft Enhancement, Immunologic,
pubmed-meshheading:9293448-Graft Survival,
pubmed-meshheading:9293448-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:9293448-Humans,
pubmed-meshheading:9293448-Immunophenotyping,
pubmed-meshheading:9293448-Leukemic Infiltration,
pubmed-meshheading:9293448-Mice,
pubmed-meshheading:9293448-Mice, Inbred NOD,
pubmed-meshheading:9293448-Mice, SCID,
pubmed-meshheading:9293448-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:9293448-Transplantation, Heterologous
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pubmed:articleTitle |
Good engraftment of B-cell precursor ALL in NOD-SCID mice.
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pubmed:affiliation |
Klinik und Poliklinik für Kinderheilkunde, Westfälische Wilhelms-Universität Münster.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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