Linked Life Data

9293377

Source:http://linkedlifedata.com/resource/pubmed/id/9293377

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-1-15
pubmed:abstractText
Family history of atherosclerosis has been recognised as an nonmodifiable cardiovascular risk factor. Lipid levels, together with hypertension and diabetes, appear to have an inheritable component. The aim of the study was to ascertain whether lipoprotein abnormalities of 169 adult patients with non-coronary atherosclerosis were associated with a family history of atherosclerosis. Besides intermediate density lipopoprotein composition and Lp(a) levels, we focused on apo(a) and apo E phenotypes, LDL cholesterol/apo B ratio, VLDL triglyceride/HDL cholesterol ratio, and environmental factors. We found that patients with a family history of atherosclerosis had a higher prevalence of VLDL triglyceride/HDL cholesterol ratio above 1.8 (51.3% vs 34.7%) than patients without. Similarly, there was a significant inverse correlation between both considered ratios (r = -0.24, p < 0.05). The odds ratio of the presence of both abnormal ratios (4.60, 95% CI, 1.41-15.00) and low molecular weight apo(a) isoforms (3.30, 95% CI, 1.05-10.30 and family history of atherosclerosis was independent of smoking and hypertension. Apo(a) isoform size seems to be more important than Lp(a) concentrations in the family history of atherosclerosis risk determination. Subsequent analysis showed that patients with a family history of atherosclerosis had a greater-than-fourfold increased risk of having one or both abnormal ratios reflecting metabolic disturbances which probably constitute a combined trait. Family history of atherosclerosis may constitute a specific lipoprotein-related marker of atherosclerosis. Such a marker often precedes the onset of overt disease and may contribute to identifying patients with an atherogenic lipoprotein profile even in the absence of classical lipid risk factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0009-8981
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
264
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-205
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9293377-Adult, pubmed-meshheading:9293377-Aged, pubmed-meshheading:9293377-Aged, 80 and over, pubmed-meshheading:9293377-Apolipoproteins E, pubmed-meshheading:9293377-Arteriosclerosis, pubmed-meshheading:9293377-Brain Ischemia, pubmed-meshheading:9293377-Cholesterol, pubmed-meshheading:9293377-Cholesterol, HDL, pubmed-meshheading:9293377-Cholesterol, VLDL, pubmed-meshheading:9293377-Family Health, pubmed-meshheading:9293377-Humans, pubmed-meshheading:9293377-Lipids, pubmed-meshheading:9293377-Lipoprotein(a), pubmed-meshheading:9293377-Lipoproteins, pubmed-meshheading:9293377-Male, pubmed-meshheading:9293377-Middle Aged, pubmed-meshheading:9293377-Peripheral Vascular Diseases, pubmed-meshheading:9293377-Phenotype, pubmed-meshheading:9293377-Risk Factors, pubmed-meshheading:9293377-Triglycerides
pubmed:year
1997
pubmed:articleTitle
Interaction of family history of atherosclerosis with atherogenic lipid traits in men with non-coronary atherosclerosis.
pubmed:affiliation
Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d'Investigació Mèdica, Barcelona, Spain. msenti@imim.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't