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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-10-9
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pubmed:abstractText |
Guinea pig pancreatic segments were superfused during 10 min with physiological saline solutions containing 10(-6) M acetylcholine (ACh) or histamine (10(-3)-10(-6) M) and the potassium concentration in the effluent [K+]o) was measured by flame photometry. Histamine evoked a transient increase in [K/]o. The removal of calcium from the superfusing solution and addition of 10(-4) M EGTA caused a significant reduction in the histamine-evoked potassium outflow. Replacement of chloride (Cl-) in the physiological salt solution by nitrate (NO3-) caused a significant reduction in the histamine-evoked potassium release. However, when Cl- was replaced by bromide (Br-) the response to histamine was unaffected. Pre-treatment of pancreatic segments with furosemide (10(-4 M) or ouabain (10(-3) M) caused a marked reduction in the histamine-induced potassium release. The results suggest that ionic requirements in histamine-evoked potassium release are the same as those in acetylcholine-evoked potassium efflux.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0034-9402
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9291535-Acetylcholine,
pubmed-meshheading:9291535-Animals,
pubmed-meshheading:9291535-Biological Transport,
pubmed-meshheading:9291535-Calcium,
pubmed-meshheading:9291535-Chlorides,
pubmed-meshheading:9291535-Diuretics,
pubmed-meshheading:9291535-Enzyme Inhibitors,
pubmed-meshheading:9291535-Furosemide,
pubmed-meshheading:9291535-Guinea Pigs,
pubmed-meshheading:9291535-Histamine,
pubmed-meshheading:9291535-Male,
pubmed-meshheading:9291535-Organ Culture Techniques,
pubmed-meshheading:9291535-Ouabain,
pubmed-meshheading:9291535-Pancreas,
pubmed-meshheading:9291535-Potassium
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pubmed:year |
1997
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pubmed:articleTitle |
Ionic requirements in histamine-evoked potassium efflux in guinea pig pancreas.
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pubmed:affiliation |
Departamento de Fisiología, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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