Linked Life Data

9291490

Source:http://linkedlifedata.com/resource/pubmed/id/9291490

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-10-23
pubmed:abstractText
The developing neuroendocrine system is thought to be a sensitive target for a number of environmental chemicals. Many of these chemicals act, not by directly damaging macromolecules but through the inappropriate modulation of normal cellular processes that regulate cell growth and differentiation patterns. As our knowledge of the specific hormones and signaling pathways involving in these functions has advanced, so has our understanding that these chemicals may act by a number of different molecular mechanisms. The dioxin-like compounds are persistent environmental contaminants. The findings that they affect cell proliferation and differentiation, are tumor promoters, and are potent immuno-, developmental, and reproductive toxicants by mechanisms not dependent on cytotoxicity, are consistent with the hypothesis that these compounds act by modulating normal cell and tissue growth processes. Furthermore, findings in exposed experimental animals and humans suggest that the developing neuroendocrine system is a sensitive target for these chemicals. All evidence to data indicates that these compounds produce their biological and toxicology affects by binding to a gene regulatory protein, the Ah receptor, whose normal function has not been clearly delineated and whose normal endogenous ligand has not been identified. Yet data on the biochemistry and molecular biology of this transcription factor indicates that well regulated and conserved pathways exist for it to mediate the transduction of biochemical signals for the control of a number of hormones and growth factors. These and other data provide evidence to suggest that the Ah receptor may be necessary for the normal development of many tissues including those in the neuroendocrine system. Further research is necessary to understand if and how it may function in this system, what the normal endogenous ligand is, and how perturbations in its activity may affect normal development processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0161-813X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
393-413
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Dioxins and the Ah receptor: probes to uncover processes in neuroendocrine development.
pubmed:affiliation
Department of Environmental Medicine, University of Rochester Medical Center, New York 14642, USA.
pubmed:publicationType
Journal Article, Review