Linked Life Data

9291143

Source:http://linkedlifedata.com/resource/pubmed/id/9291143

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-10-23
pubmed:abstractText
Whole cell patch-clamp recordings were performed on freshly dissociated rat retinal ganglion cells to determine the action of Angiotensin II (AngII) on voltage-activated calcium current subtypes in this cell type. AngII had no effect on a toxin-resistant calcium current component; N-type currents were reduced by 27 +/- 5% in all retinal ganglion cells (RGCs) tested; L-type currents were reduced by 33 +/- 7% in 59% of the RGCs but increased by 31 +/- 6% in 41% of the cells. AngII effects were reversible within a few seconds through reperfusion with bath solution and calcium current kinetics and current-voltage relations remained unaffected. The net effect of AngII in a single RGC is either a reduction or an enhancement of the total calcium current, dependent on (1) the number of L-type channels compared to N-type channels and (2) on the kind of action AngII exerts on L-type channels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
231
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-4
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Angiotensin II-induced inhibition and facilitation of calcium current subtypes in rat retinal ganglion cells.
pubmed:affiliation
Department of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital Tübingen, Germany. elke.guenther@uni-tuebingen.de
pubmed:publicationType
Journal Article