Linked Life Data

9290409

Source:http://linkedlifedata.com/resource/pubmed/id/9290409

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-9-18
pubmed:abstractText
Exogenous administration of adenosine induces atrial fibrillation in up to 7.0% of patients. Animal studies affirm endogenous adenosine released in response to tissue hypoxia may play a mechanistic role in arrhythmias associated with myocardial ischaemia or hypoxia. Therefore, atrial fibrillation occurring early after the acute phase of myocardial infarction involving atrial tissue may be secondary to an excessive accumulation of adenosine that leads to a shortening of atrial refractory period. Early in the course of acute inferior myocardial infarction, two patients (males aged 45 and 68) suffered new onset sustained atrial fibrillation that was abrupt in onset and complicated their clinical management. They were administered 250 mg theophylline as a slow intravenous injection at a rate of 100 mg/min or until conversion to normal sinus rhythm occurred. Both patients converted to normal sinus rhythm within five minutes of the administration of theophylline. In up to 52 hours of continuous ECG monitoring after the theophylline administration the atrial fibrillation did not recur. Neither patient experienced any adverse outcome from theophylline administration. These observations are the first reported in humans or laboratory animals to suggest that atrial fibrillation, presumably due to elevated interstitial atrial concentration of adenosine caused by myocardial ischaemia, can be terminated with an adenosine receptor antagonist. However, the hypothesis that excessive accumulation of endogenous adenosine in atrial tissue may induce atrial fibrillation is well substantiated by other investigators. Thus, A1 adenosine receptor antagonists may prove to be valuable in the management of ischaemia related atrial fibrillation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-1486587, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-164557, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-2193560, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-2598420, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-2664879, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-4019929, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-475515, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-7661495, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-7896004, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-7954650, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-7985614, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-8087292, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-8124809, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-8296744, http://linkedlifedata.com/resource/pubmed/commentcorrection/9290409-8944814
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1355-6037
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-90
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Myocardial infarction related atrial fibrillation: role of endogenous adenosine.
pubmed:affiliation
Department of Internal Medicine, University of Florida, Health Sciences Center, Gainesville 32610, USA.
pubmed:publicationType
Journal Article, Case Reports