Linked Life Data

928951

Source:http://linkedlifedata.com/resource/pubmed/id/928951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-1-27
pubmed:abstractText
Melittin, a membrane-active peptide of bee venom, as well as synthetic melittin, stimulated the biosynthesis of prostaglandins by mouse transformed fibroblasts (MC5-5), human fibroblasts (D550), rabbit aorta endothelial cells (CLO), rat lung type II alveolar pneumocytes (L-2) and rabbit smooth muscle cells (R-I). The melittin peptides also stimulated the release of arachidonic acid from the cellular phospholipids of MC5-5 cells. The stimulated prostaglandin biosynthesis by MC5-5 cells was inhibited by indomethacin and dexamethasone. Dexamethasone inhibited also the release of arachidonic acid by MC5-5 cells. In mice, intraperitoneal inoculation of melittin increased 13,14-dihydro-15-keto-PGE2 levels in peripheral blood. Prior injections of the mice with indomethacin prevented the melittin-induced increase in this PGE2 metabolite.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-17
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.