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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-10-2
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pubmed:abstractText |
Olomoucine and roscovitine are novel compounds that are designed to inhibit cyclin-dependent kinases (e.g., Cdk2 and cdc2). Cdks regulate progression through key checkpoints of the cell cycle. The purpose of this study was to determine (1) whether olomoucine and roscovitine inhibit Cdk2 and cdc2 kinase activities of the human gastric cancer cell line SIIA and (2) whether olomoucine and roscovitine block cell proliferation and cell cycle progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CDC2 Protein Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/CDC2-CDC28 Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/CDK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Kinetin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/olomoucine,
http://linkedlifedata.com/resource/pubmed/chemical/roscovitine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-94; discussion 194-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9288122-Antineoplastic Agents,
pubmed-meshheading:9288122-CDC2 Protein Kinase,
pubmed-meshheading:9288122-CDC2-CDC28 Kinases,
pubmed-meshheading:9288122-Cell Cycle,
pubmed-meshheading:9288122-Cell Division,
pubmed-meshheading:9288122-Cyclin-Dependent Kinase 2,
pubmed-meshheading:9288122-Cyclin-Dependent Kinases,
pubmed-meshheading:9288122-Enzyme Inhibitors,
pubmed-meshheading:9288122-Histones,
pubmed-meshheading:9288122-Humans,
pubmed-meshheading:9288122-Kinetics,
pubmed-meshheading:9288122-Kinetin,
pubmed-meshheading:9288122-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9288122-Purines,
pubmed-meshheading:9288122-Stomach Neoplasms,
pubmed-meshheading:9288122-Substrate Specificity,
pubmed-meshheading:9288122-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells.
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pubmed:affiliation |
Department of Surgery, University of Texas Medical Branch, Galveston 77555-0542, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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