Linked Life Data

928476

Source:http://linkedlifedata.com/resource/pubmed/id/928476

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-1-27
pubmed:abstractText
Drinking of etonitazene HCl by 6 rats was studied during daily 4-hr sessions. Five related experiments were conducted sequentially. In the first experiment schedule-induced polydipsia was established. Subsequently, etonitazene concentrations (1.25, 2.5 and 5.0 microgram/ml) were substituted for water, and intake of large quantities of the drug occurred. In the second experiment the concurrent food reinforcement schedule was discontinued and lever presses maintained by etonitazene (5 microgram/ml) persisted. In the third experiment the number of lever presses, required per dipper presentation of etonitazene (5 microgram/ml) was increased, and rate of lever pressing increased directly with the response requirement whereas number of dipper presentations remained constant. In the fourth experiment water was substituted for the 5 microgram/ml etonitazene solution. Water responding declined to low rates, but when etonitazene was reintroduced, responding increased to previous levels. Thus, etonitazene (5 microgram/ml) was functioning as a positive reinforcer. In the final experiment, progressive increases in the etonitazene concentration (5, 10, 20 and 40 microgram/ml) resulted in both systematic decreases in response rate and increases in quantity (microgram) consumed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-203
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Establishment of etonitazene as a reinforcer for rats by use of schedule-induced drinking.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.