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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-10-20
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pubmed:abstractText |
The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer forms a Z-DNA d(CGCGCG)2 with 5'-overhang G residues instead of an A-DNA d(GCGCGC)2 with 3'-overhang G residues. The overhang G residues from parallel strands of two adjacent duplexes form a trans reverse Hoogsteen G x G basepair that stacks on the six Z-DNA basepairs to produce a pseudocontinuous helix. The reverse Hoogsteen G x G basepair is unusual in that the displacement of one G base relative to the other allows them to participate in a bifurcated (G1)N2 . . . N7(G8) and an enhanced (G8)C8-H . . . O6(G1) hydrogen bond, in addition to the two usual hydrogen bonds. The 5'-overhang G residues are anti and C2'-endo while the 3'-terminal G residues are syn and C2'-endo. The conformations of both G residues are different from the syn/C3'-endo for the guanosine in a standard Z-DNA. The two cobalt hexammine ions bind to the phosphate groups in both GpC and CpG steps in Z(I) and Z(II) conformations. The water structure motif is similar to the other Z-DNA structures.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284322-1384741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284322-1396572,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9284322-8873995
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1553-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9284322-Base Composition,
pubmed-meshheading:9284322-Base Sequence,
pubmed-meshheading:9284322-Circular Dichroism,
pubmed-meshheading:9284322-Cobalt,
pubmed-meshheading:9284322-Crystallography, X-Ray,
pubmed-meshheading:9284322-DNA,
pubmed-meshheading:9284322-Guanine,
pubmed-meshheading:9284322-Hydrogen Bonding,
pubmed-meshheading:9284322-Models, Molecular,
pubmed-meshheading:9284322-Nucleic Acid Conformation,
pubmed-meshheading:9284322-Oligodeoxyribonucleotides
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pubmed:year |
1997
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pubmed:articleTitle |
Crystal structure of d(GCGCGCG) with 5'-overhang G residues.
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pubmed:affiliation |
Biological Macromolecular Structure Center, Department of Chemistry, The Ohio State University, Columbus 43210-1002, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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