|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1997-9-19
|
|
pubmed:abstractText |
Cytokines are suspected to play an important role in systemic infections by group B streptococci (GBS), an important cause of neonatal sepsis. This work was undertaken to determine if interleukin 12 (IL-12) is produced in mouse pups infected with GBS and has a role in this sepsis model. IL-12 elevations were measured by both an enzyme-linked immunosorbent assay and a bioassay in plasma samples obtained from 12 to 72 h after GBS challenge. Pretreatment with neutralizing anti-IL-12 antibodies significantly increased lethality and blood CFU (P < 0.05). Conversely, either prophylactically or therapeutically administered recombinant IL-12 (rIL-12) significantly improved survival time and decreased blood CFU. Since these beneficial effects were associated with increased spleen gamma interferon (IFN-gamma) production, we examined whether the latter cytokine mediated the observed rIL-12 effects. Pretreatment with neutralizing anti-IFN-gamma monoclonal antibodies significantly counteracted the beneficial effects of rIL-12 on lethality. Our data indicate that rIL-12 is a possible candidate for treatment of GBS sepsis and that its activities in this model are at least partially mediated by IFN-gamma.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-1357073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-1672545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-1910003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-2037782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-2504877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-3081678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-3520322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7595199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7612223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7650381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7650384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7688022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7769309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7809149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7907107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7909326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7911289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7915739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7920463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7927780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7938013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-7963574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8096238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8097524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8100997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8102154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8103338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8418044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8598471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8606095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8698455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8698523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8757817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-8816374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9284145-9207363
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0019-9567
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3731-5
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9284145-Animals,
pubmed-meshheading:9284145-Animals, Newborn,
pubmed-meshheading:9284145-Interferon-gamma,
pubmed-meshheading:9284145-Interleukin-12,
pubmed-meshheading:9284145-Mice,
pubmed-meshheading:9284145-Mice, Inbred BALB C,
pubmed-meshheading:9284145-Sepsis,
pubmed-meshheading:9284145-Streptococcal Infections,
pubmed-meshheading:9284145-Streptococcus agalactiae,
pubmed-meshheading:9284145-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Role of interleukin 12 in experimental neonatal sepsis caused by group B streptococci.
|
|
pubmed:affiliation |
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Messina, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
