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pubmed-article:9281527pubmed:abstractTextThe protein enzymes RNA ligase and DNA ligase catalyze the ligation of nucleic acids via an adenosine-5'-5'-pyrophosphate 'capped' RNA or DNA intermediate. The activation of nucleic acid substrates by adenosine 5'-monophosphate (AMP) may be a vestige of 'RNA world' catalysis. AMP-activated ligation seems ideally suited for catalysis by ribozymes (RNA enzymes), because an RNA motif capable of tightly and specifically binding AMP has previously been isolated.lld:pubmed
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pubmed-article:9281527pubmed:articleTitleIsolation of novel ribozymes that ligate AMP-activated RNA substrates.lld:pubmed
pubmed-article:9281527pubmed:affiliationDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.lld:pubmed
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