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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1997-10-20
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pubmed:abstractText |
The protein enzymes RNA ligase and DNA ligase catalyze the ligation of nucleic acids via an adenosine-5'-5'-pyrophosphate 'capped' RNA or DNA intermediate. The activation of nucleic acid substrates by adenosine 5'-monophosphate (AMP) may be a vestige of 'RNA world' catalysis. AMP-activated ligation seems ideally suited for catalysis by ribozymes (RNA enzymes), because an RNA motif capable of tightly and specifically binding AMP has previously been isolated.
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
607-17
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9281527-Adenosine Monophosphate,
pubmed-meshheading:9281527-Base Sequence,
pubmed-meshheading:9281527-Binding Sites,
pubmed-meshheading:9281527-Catalysis,
pubmed-meshheading:9281527-DNA Ligases,
pubmed-meshheading:9281527-Directed Molecular Evolution,
pubmed-meshheading:9281527-Kinetics,
pubmed-meshheading:9281527-Ligands,
pubmed-meshheading:9281527-Molecular Sequence Data,
pubmed-meshheading:9281527-Nucleic Acid Conformation,
pubmed-meshheading:9281527-RNA,
pubmed-meshheading:9281527-RNA, Catalytic,
pubmed-meshheading:9281527-RNA Ligase (ATP),
pubmed-meshheading:9281527-Substrate Specificity
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pubmed:year |
1997
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pubmed:articleTitle |
Isolation of novel ribozymes that ligate AMP-activated RNA substrates.
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pubmed:affiliation |
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.
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