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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1980-2-15
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pubmed:abstractText |
Human lung tissue passively sensitized with anti-grass pollen IgE antibodies release histamine upon exposure to specific grass pollen antigen. Fenoterol, a beta 2-sympathomimetic stimulator drug, is shown to be a potent inhibitor of antigen-induced release of histamine. This inhibitory effect occurred with fenoterol concentrations of 2 x 10(-8) to 1 x 10(-7) M, and was determined by 67 and 95%, respectively. Thus, the beta 2-receptor stimulator fenoterol is a valuable drug for treating allergic bronchial asthma since it exhibits a combination of prophylactic and direct therapeutic properties.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0025-7931
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
38
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
163-7
|
pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:92803-Asthma,
pubmed-meshheading:92803-DNA,
pubmed-meshheading:92803-Dose-Response Relationship, Drug,
pubmed-meshheading:92803-Ethanolamines,
pubmed-meshheading:92803-Fenoterol,
pubmed-meshheading:92803-Histamine Release,
pubmed-meshheading:92803-Humans,
pubmed-meshheading:92803-Immunoglobulin E,
pubmed-meshheading:92803-Lung,
pubmed-meshheading:92803-Poaceae,
pubmed-meshheading:92803-Pollen
|
pubmed:year |
1979
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pubmed:articleTitle |
Immunological release of histamine from human lung. I. Studies on the beta 2-sympathomimetic stimulator fenoterol.
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pubmed:publicationType |
Journal Article,
In Vitro
|