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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0008779,
umls-concept:C0009015,
umls-concept:C0017612,
umls-concept:C0023621,
umls-concept:C0027096,
umls-concept:C0033684,
umls-concept:C0086418,
umls-concept:C0205653,
umls-concept:C0216706,
umls-concept:C0679058,
umls-concept:C1314939,
umls-concept:C1334043,
umls-concept:C1417573,
umls-concept:C1547699,
umls-concept:C1880022,
umls-concept:C2697616,
umls-concept:C2700640
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pubmed:issue |
2
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pubmed:dateCreated |
1997-9-23
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pubmed:databankReference |
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pubmed:abstractText |
A group of cDNAs isolated from a subtractive ciliary body library of a normal human eye donor revealed 100% identity with TIGR a candidate gene responsible for juvenile open zangle glaucoma [Science 275 (1997) 668-670]. Several structural features of the deduced human protein have been noted: a cleavable N-terminal signal peptide, a periodic repetition at the N-terminus of leucine and arginine residues at every seventh and eleven position respectively in helix conformation (leucine zipper-like motif) exhibiting homology with myosin, and with olfactomedin in the C-terminus. The mRNA for TIGR is abundantly expressed in the ciliary body, iris, heart and skeletal muscle.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myosins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/olfactomedin,
http://linkedlifedata.com/resource/pubmed/chemical/trabecular meshwork-induced...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
413
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
349-53
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9280311-Amino Acid Sequence,
pubmed-meshheading:9280311-Base Sequence,
pubmed-meshheading:9280311-Ciliary Body,
pubmed-meshheading:9280311-Cloning, Molecular,
pubmed-meshheading:9280311-Cytoskeletal Proteins,
pubmed-meshheading:9280311-DNA, Complementary,
pubmed-meshheading:9280311-Extracellular Matrix Proteins,
pubmed-meshheading:9280311-Eye,
pubmed-meshheading:9280311-Eye Proteins,
pubmed-meshheading:9280311-Gene Library,
pubmed-meshheading:9280311-Glaucoma, Open-Angle,
pubmed-meshheading:9280311-Glycoproteins,
pubmed-meshheading:9280311-Humans,
pubmed-meshheading:9280311-Molecular Sequence Data,
pubmed-meshheading:9280311-Myosins,
pubmed-meshheading:9280311-Organ Specificity,
pubmed-meshheading:9280311-RNA, Messenger,
pubmed-meshheading:9280311-Sequence Homology, Amino Acid,
pubmed-meshheading:9280311-Sequence Homology, Nucleic Acid
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pubmed:year |
1997
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pubmed:articleTitle |
Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.
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pubmed:affiliation |
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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