Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1997-10-6
pubmed:abstractText
The pituitary glycoprotein hormones LH and FSH regulate the reproductive cycle and are sensitive to feedback by gonadal steroids. The common alpha-subunit shared by these hormones is transcriptionally repressed by androgen receptor (AR) in the presence of its ligand dihydrotestosterone. This identifies at least one mechanism that contributes to AR-dependent suppression of gonadotropin synthesis. Repression of alpha-subunit transcription by AR requires only the sequences within the first 480 bp of the promoter. While this region contains a high-affinity binding site for AR, this element does not mediate the suppressive effects of androgens. Instead, two other elements within the promoter-regulatory region (alpha-basal element and cAMP-regulatory element), which are important for expression of the alpha-subunit gene in gonadotropes, mediate the effects of AR. This suggests that AR inhibits activity of the alpha-subunit promoter by interfering with the transcriptional properties of the proteins that bind to alpha-basal element and the cAMP-regulatory elements. Furthermore, transfection analysis of various mutant ARs identified both the DNA-binding and ligand-binding domains of the receptor as critical for repression. Comparisons with the MMTV promoter revealed distinct structural requirements that underlie the transactivation and transrepression properties of AR.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1109895, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1370794, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1370795, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1373809, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1379672, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1446821, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1537831, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1701137, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1704103, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1712910, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1736308, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-1985913, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-2108012, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-2111188, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-2154035, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-2169353, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-2172802, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-3216867, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-3805009, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-4068701, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-470390, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-6207567, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-6781545, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-6781548, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-7476976, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-7515001, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-7592867, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-7685765, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-7708066, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-7769130, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-7791760, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-7913207, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8028671, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8114755, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8175737, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8521509, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8530400, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8616895, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8631889, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8798622, http://linkedlifedata.com/resource/pubmed/commentcorrection/9280065-8940185
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0888-8809
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1497-506
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Transcriptional repression of the alpha-subunit gene by androgen receptor occurs independently of DNA binding but requires the DNA-binding and ligand-binding domains of the receptor.
pubmed:affiliation
Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City 66160, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.