rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1997-10-6
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pubmed:abstractText |
The pituitary glycoprotein hormones LH and FSH regulate the reproductive cycle and are sensitive to feedback by gonadal steroids. The common alpha-subunit shared by these hormones is transcriptionally repressed by androgen receptor (AR) in the presence of its ligand dihydrotestosterone. This identifies at least one mechanism that contributes to AR-dependent suppression of gonadotropin synthesis. Repression of alpha-subunit transcription by AR requires only the sequences within the first 480 bp of the promoter. While this region contains a high-affinity binding site for AR, this element does not mediate the suppressive effects of androgens. Instead, two other elements within the promoter-regulatory region (alpha-basal element and cAMP-regulatory element), which are important for expression of the alpha-subunit gene in gonadotropes, mediate the effects of AR. This suggests that AR inhibits activity of the alpha-subunit promoter by interfering with the transcriptional properties of the proteins that bind to alpha-basal element and the cAMP-regulatory elements. Furthermore, transfection analysis of various mutant ARs identified both the DNA-binding and ligand-binding domains of the receptor as critical for repression. Comparisons with the MMTV promoter revealed distinct structural requirements that underlie the transactivation and transrepression properties of AR.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0888-8809
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1497-506
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:9280065-Animals,
pubmed-meshheading:9280065-Binding Sites,
pubmed-meshheading:9280065-DNA,
pubmed-meshheading:9280065-DNA-Binding Proteins,
pubmed-meshheading:9280065-Follicle Stimulating Hormone,
pubmed-meshheading:9280065-Ligands,
pubmed-meshheading:9280065-Luteinizing Hormone,
pubmed-meshheading:9280065-Mice,
pubmed-meshheading:9280065-Pituitary Gland,
pubmed-meshheading:9280065-Receptors, Androgen,
pubmed-meshheading:9280065-Signal Transduction,
pubmed-meshheading:9280065-Transcriptional Activation
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pubmed:year |
1997
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pubmed:articleTitle |
Transcriptional repression of the alpha-subunit gene by androgen receptor occurs independently of DNA binding but requires the DNA-binding and ligand-binding domains of the receptor.
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pubmed:affiliation |
Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City 66160, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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