Linked Life Data

9279248

Source:http://linkedlifedata.com/resource/pubmed/id/9279248

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1997-9-18
pubmed:abstractText
Sepsis is the most common factor leading to the acute respiratory distress syndrome (ARDS) and is associated with the highest mortality rate. It has been suggested that the pulmonary surfactant system is altered and contributes to the lung dysfunction associated with ARDS. The objective of this study was to characterize the lung injury, specifically the endogenous surfactant system in septic adult rats. Sepsis was induced in male Sprague-Dawley rats by cecal ligation and perforation and resulted in significant increases in heart rates, respiratory rates, and lactate levels along with positive blood cultures in septic animals compared with a sham control group. Two distinct septic groups were developed, a septic group and a sepsis with lung injury (septic+LI) group. The septic group had no significant differences in oxygenation compared with the sham group, whereas the septic+LI group had significantly lower PaO2 and higher A-a gradient values compared to both the sham and septic groups. The total surfactant pool size was significantly lower in the septic+LI group compared with the sham group. The small surfactant aggregate to large surfactant aggregate ratio was significantly lower in the septic group and was further reduced in the septic+LI group. There were also significantly higher levels of surfactant protein A (SP-A) in both septic and septic+LI groups compared to the sham group. These results demonstrated that the endogenous surfactant system was altered in systemic sepsis without lung dysfunction and is further altered when a lung injury is present.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
617-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9279248-Analysis of Variance, pubmed-meshheading:9279248-Animals, pubmed-meshheading:9279248-Bronchoalveolar Lavage Fluid, pubmed-meshheading:9279248-Disease Models, Animal, pubmed-meshheading:9279248-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:9279248-Glycoproteins, pubmed-meshheading:9279248-Lung, pubmed-meshheading:9279248-Male, pubmed-meshheading:9279248-Proteolipids, pubmed-meshheading:9279248-Pulmonary Surfactant-Associated Protein A, pubmed-meshheading:9279248-Pulmonary Surfactant-Associated Proteins, pubmed-meshheading:9279248-Pulmonary Surfactants, pubmed-meshheading:9279248-Rats, pubmed-meshheading:9279248-Rats, Sprague-Dawley, pubmed-meshheading:9279248-Respiratory Distress Syndrome, Adult, pubmed-meshheading:9279248-Surface Tension, pubmed-meshheading:9279248-Systemic Inflammatory Response Syndrome
pubmed:year
1997
pubmed:articleTitle
Alterations of the endogenous surfactant system in septic adult rats.
pubmed:affiliation
Department of Physiology, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Canada. jmalloy@julian.uwo.ca
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't