Linked Life Data

927879

Source:http://linkedlifedata.com/resource/pubmed/id/927879

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-1-27
pubmed:abstractText
The effect of morphine microinjection (5 microgram/0.5 microliter) and focal electrical stimulation on the animal's response to radiant heat and noxious pinch was studied concurrently at 117 brain loci extending from the medial thalamus caudally to the periaqueductal gray area (PAG). Three populations of brain sites were discernible based on their responsiveness to focal electrical stimulation and morphine microinjection in the production of antinociception: (a) sites which support stimulation-produced analgesia (SPA, n = 24), (b) sites which were sensitive to the direct application of morphine (n = 8), (c) sites responsive to both manipulations (n = 8). With a few exceptions, all morphine sensitive sites were located within the anatomical boundaries of the PAG while sites supporting SPA were located not only within the PAG but also in the brain regions peripheral to this structure. Sites responsive to both manipulations were generally distributed throughout thf lateral aspect of the posteroventral PAG. Stimulation strength-effect curves for sites subserving SPA were also obtained. No differences were discovered between curves obtained from morphine-sensitive and -insensitive brain loci.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0304-3959
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Concurrent mapping of brain sites for sensitivity to the direct application of morphine and focal electrical stimulation in the production of antinociception in the rat.
pubmed:publicationType
Journal Article, Comparative Study