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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-9-19
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pubmed:abstractText |
We previously reported that a mouse mammary tumor virus (MMTV(II-TES14)), encoding a superantigen specific for TCR Vbeta14, can infect lymph node (LN) cells of mice in an I-E-independent manner. Here we examined the kinetics of cell types infected with exogenous MMTV in the draining LN after s.c. injection of II-TES milk containing MMTV(II-TES14). The infectivity was assessed in LN cells sorted into each cell subset by a semiquantitative analysis of MMTV provirus using PCR with a primer specific for MMTV(II-TES14). Only B cells in the LN were infected by the MMTV on day 6 after injection, but CD8+ T cells and, to a lesser extent, CD4+ T cells were also found to be detectably infected on day 14 after the injection of II-TES milk. Among the T cells we examined, Vbeta8 T cells were most preferentially infected with MMTV, but no Vbeta14 T cells specific for MMTV(II-TES14) superantigen were infected on day 14 after infection. The transfer of Vbeta8 T cells sorted from mice injected with II-TES milk 14 days previously resulted in the deletion of CD4+ Vbeta14 T cells and in the MMTV infection of normal B6 mice. No MMTV infection of T cells occurred in IgM knockout mice, which lack a mature B cell compartment. These results suggest that MMTV surviving in B cells is transferred to Vbeta8 T cells, which may play an important role in MMTV longevity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/I-E-antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2189-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9278306-Animals,
pubmed-meshheading:9278306-Antigens, Viral,
pubmed-meshheading:9278306-B-Lymphocytes,
pubmed-meshheading:9278306-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9278306-Crosses, Genetic,
pubmed-meshheading:9278306-Disease Susceptibility,
pubmed-meshheading:9278306-Female,
pubmed-meshheading:9278306-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:9278306-Histocompatibility Antigens Class II,
pubmed-meshheading:9278306-Immunoglobulin M,
pubmed-meshheading:9278306-Injections, Subcutaneous,
pubmed-meshheading:9278306-Mammary Neoplasms, Experimental,
pubmed-meshheading:9278306-Mammary Tumor Virus, Mouse,
pubmed-meshheading:9278306-Mice,
pubmed-meshheading:9278306-Mice, Inbred DBA,
pubmed-meshheading:9278306-Mice, Knockout,
pubmed-meshheading:9278306-Milk,
pubmed-meshheading:9278306-Pregnancy,
pubmed-meshheading:9278306-Protein Binding,
pubmed-meshheading:9278306-RNA, Viral,
pubmed-meshheading:9278306-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9278306-Retroviridae Infections,
pubmed-meshheading:9278306-Superantigens,
pubmed-meshheading:9278306-T-Lymphocyte Subsets,
pubmed-meshheading:9278306-Tumor Virus Infections
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pubmed:year |
1997
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pubmed:articleTitle |
T cells bearing Vbeta8 are preferentially infected with exogenous mouse mammary tumor virus.
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pubmed:affiliation |
Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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