Linked Life Data

9278105

Source:http://linkedlifedata.com/resource/pubmed/id/9278105

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-10-1
pubmed:abstractText
We studied the ability of the pancreas in the aspect of histological, biochemical and functional changes (pancreatic blood flow, serum and pancreatic amylase levels, DNA and RNA content and pancreatic mass) to recover from repeated episodes of caerulein-induced acute pancreatitis. The experiment was carried out in three animal groups: group I receiving one infusion of caerulein, group II receiving two infusions of caerulein at the interval of 10 days, and group III with three infusions every 10 days. It was found that histological signs of acute pancreatitis after the first caerulein infusion showed regression after 3 days, and the process of regeneration was almost completed after 10 days. The content of DNA and RNA correlated with the histological picture. At this time interval also the level of amylase was returning to normal. Each subsequent infusion of caerulein resulted in less enhanced tissue destruction, but regeneration started later. Pancreatic blood flow was decreased each time after induction of pancreatitis, whereas normalization was more rapid. The present findings indicate that the pancreas adapts to repeated injury, which is manifested by decreased severity of changes, but the process of regeneration is delayed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1233-9687
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-101
pubmed:dateRevised
2007-8-1
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Adaptation of the pancreas to repeated caerulein administration in rats. A morphological and functional study.
pubmed:affiliation
Department of Clinical and Experimental Pathomorphology, Jagiellonian University Medical College, Kraków.
pubmed:publicationType
Journal Article