Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2 Pt 1
|
pubmed:dateCreated |
1997-9-24
|
pubmed:abstractText |
To determine the interrelationship among insulin action, total or regional adiposity, and sex, we measured insulin-mediated glucose disposal by the euglycemic insulin clamp and adipose distribution using computed axial tomography (22 scans) in 32 black men and 20 black women with non-insulin-dependent diabetes mellitus (age 48 +/- 9 and 54 +/- 9 yr, body mass index 26.3 +/- 2.3 and 27.2 +/- 2.6 kg/m2, respectively). Women had approximately 80% more total and subcutaneous fat volume than men (31.8 +/- 8.3 vs. 18.6 +/- 6.1 and 28.5 +/- 7.3 vs. 14.7 +/- 4.6 liters) and less muscle volume (22.9 +/- 3.7 vs. 35.1 +/- 3.8 liters). Visceral fat volume did not differ between men and women (3.49 +/- 1.65 vs. 2.96 +/- 1.22 liters). Despite these body composition differences, an inverse nonlinear relationship existed between glucose disposal and visceral fat independent of sex (r = -0.58, P < 0.0001; men r = -0.60 and women r = -0.59; the slope and intercept were not different in men and women). Visceral fat explained a significant portion (34%) of variance in insulin-mediated glucose disposal, whereas total or subcutaneous fat and sex did not. Visceral fat appears to affect glucose disposal over a restricted range (up to approximately 2.5 l/m2 body surface area.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0002-9513
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
273
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
E425-32
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:9277397-Adipose Tissue,
pubmed-meshheading:9277397-Adult,
pubmed-meshheading:9277397-African Continental Ancestry Group,
pubmed-meshheading:9277397-Body Composition,
pubmed-meshheading:9277397-Diabetes Mellitus, Type 2,
pubmed-meshheading:9277397-Female,
pubmed-meshheading:9277397-Glucose,
pubmed-meshheading:9277397-Glucose Clamp Technique,
pubmed-meshheading:9277397-Humans,
pubmed-meshheading:9277397-Male,
pubmed-meshheading:9277397-Middle Aged,
pubmed-meshheading:9277397-Sex Characteristics,
pubmed-meshheading:9277397-Viscera
|
pubmed:year |
1997
|
pubmed:articleTitle |
Relationship of visceral adipose tissue and glucose disposal is independent of sex in black NIDDM subjects.
|
pubmed:affiliation |
Department of Medicine, State University of New York Health Science Center at Brooklyn 11203, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|