Linked Life Data

9276079

Source:http://linkedlifedata.com/resource/pubmed/id/9276079

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-10-17
pubmed:abstractText
Mismatch negativities (MMNs) of the event-related potential to deviant tones and environmental sounds were recorded during active and ignore oddball sequences in young and elderly controls and patients with probable Alzheimer's disease (PAD). MMNs were smaller in the PAD waveforms compared to those of the controls, suggesting a degraded sensory memory trace in these subjects; however, under ignore conditions, environmental sounds elicited robust MMNs in the PAD group along with N2b and novelty P3 components in similar fashion to controls. As N2b and P3 are usually elicited by attended stimuli, these data suggest that in the PAD subjects, the highly deviant events involuntarily captured attention, perhaps reflecting the activation of an attentional switching mechanism. Because this passive switching is thought to reflect activation of a mechanism located in the frontal lobes, the data suggest that this putative frontal lobe mechanism is relatively intact in the early stages of the disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-3223
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
382-402
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Mismatch negativity during attend and ignore conditions in Alzheimer's disease.
pubmed:affiliation
Department of Psychology, Behrend College, Erie, Pennsylvania, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S.