Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1997-10-27
pubmed:abstractText
Agmatine has been tested i.v. in alpha-chloralose anaesthetised rats for its effects on spinal nociceptive reflexes evoked by mechanical and electrical stimuli. Agmatine did not affect reflexes until very high doses (200 mg/kg, i.v.) which also caused complex cardiovascular disturbances. In spinally intact rats agmatine reduced reflexes; it was slightly less potent when there was carrageenan-induced hind paw inflammation. The alpha2-adrenoceptor antagonist atipamezole (80 microg/kg) did not significantly affect these reductions. In spinalised animals, agmatine caused a generalised increase in background firing which in animals with a non-inflamed paw was significantly reduced after atipamezole. There was no significant change in evoked responses once corrected for background activity. In all groups of animals agmatine, when administered at various doses and times prior to the mu-opioid receptor agonist fentanyl, had no effect on the ID50 of fentanyl.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
331
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-8
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed-meshheading:9274971-Adrenergic alpha-Antagonists, pubmed-meshheading:9274971-Agmatine, pubmed-meshheading:9274971-Analgesics, Opioid, pubmed-meshheading:9274971-Animals, pubmed-meshheading:9274971-Blood Pressure, pubmed-meshheading:9274971-Electric Stimulation, pubmed-meshheading:9274971-Fentanyl, pubmed-meshheading:9274971-Hindlimb, pubmed-meshheading:9274971-Male, pubmed-meshheading:9274971-Motor Neurons, pubmed-meshheading:9274971-Muscle, Skeletal, pubmed-meshheading:9274971-Nociceptors, pubmed-meshheading:9274971-Physical Stimulation, pubmed-meshheading:9274971-Rats, pubmed-meshheading:9274971-Rats, Wistar, pubmed-meshheading:9274971-Receptors, Adrenergic, alpha-2, pubmed-meshheading:9274971-Receptors, Opioid, mu, pubmed-meshheading:9274971-Reflex, pubmed-meshheading:9274971-Spinal Cord
pubmed:year
1997
pubmed:articleTitle
Effect of agmatine on spinal nociceptive reflexes: lack of interaction with alpha2-adrenoceptor or mu-opioid receptor mechanisms.
pubmed:affiliation
Department of Physiology, School of Medical Sciences, University Walk, Bristol, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't