| pubmed-article:9274632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9274632 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9274632 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:9274632 | lifeskim:mentions | umls-concept:C0681854 | lld:lifeskim |
| pubmed-article:9274632 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:9274632 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9274632 | pubmed:dateCreated | 1997-9-19 | lld:pubmed |
| pubmed-article:9274632 | pubmed:abstractText | Tyrosine is a precursor of melanin synthesis and might thus present a valuable marker for melanoma. The aim of this study was to evaluate the uptake of alpha-methyl-tyrosine (AMT) in melanoma cell cultures and to assess its usefulness as a radiopharmaceutical for staging melanoma patients with whole-body scintigraphy. Melanoma (M19-cell lines) and fibroblast (negative control) cell cultures were incubated with 125I-AMT and the radioactive uptake in the cell lines was measured in a gamma-counter over 24 h. For in vivo studies, planar whole-body scintigraphy and single photon emission computed tomography (SPECT) of the tumour region was performed following injection of 250-350 MBq 123I-AMT in six patients with known melanoma metastases. Findings were compared with results of whole-body positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) as a standard of reference. Fibroblasts showed an unchanged uptake of (mean +/- SD) 0.56 +/- 0.09% 15 min and 0.066 +/- 0.09% 24 h, respectively, after incubation of 125I-AMT, whereas there was an increased uptake in melanoma cell cultures over time from 0.9 +/- 0.05% to 7.5 +/- 1.6%. In staging melanoma patients, the sensitivity of whole-body AMT-scintigraphy compared with FDG-PET was 37% (10 of 27 metastases). AMT is transported and metabolized to a high extent in melanoma cells and 123I-AMT is accumulated in melanoma metastases. Owing to its low sensitivity, however, the clinical use of whole-body AMT scintigraphy cannot be recommended. | lld:pubmed |
| pubmed-article:9274632 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9274632 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9274632 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9274632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9274632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9274632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9274632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9274632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9274632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9274632 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9274632 | pubmed:issn | 0007-0963 | lld:pubmed |
| pubmed-article:9274632 | pubmed:author | pubmed-author:MeyerJJ | lld:pubmed |
| pubmed-article:9274632 | pubmed:author | pubmed-author:AVISK EKE | lld:pubmed |
| pubmed-article:9274632 | pubmed:author | pubmed-author:WesteraGG | lld:pubmed |
| pubmed-article:9274632 | pubmed:author | pubmed-author:SteinertHH | lld:pubmed |
| pubmed-article:9274632 | pubmed:author | pubmed-author:Von... | lld:pubmed |
| pubmed-article:9274632 | pubmed:author | pubmed-author:DummerRR | lld:pubmed |
| pubmed-article:9274632 | pubmed:author | pubmed-author:BöniRR | lld:pubmed |
| pubmed-article:9274632 | pubmed:author | pubmed-author:Huch BöniRR | lld:pubmed |
| pubmed-article:9274632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9274632 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:9274632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9274632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9274632 | pubmed:pagination | 96-100 | lld:pubmed |
| pubmed-article:9274632 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9274632 | pubmed:meshHeading | pubmed-meshheading:9274632-... | lld:pubmed |
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| pubmed-article:9274632 | pubmed:meshHeading | pubmed-meshheading:9274632-... | lld:pubmed |
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| pubmed-article:9274632 | pubmed:meshHeading | pubmed-meshheading:9274632-... | lld:pubmed |
| pubmed-article:9274632 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9274632 | pubmed:articleTitle | Radioiodine-labelled alpha-methyl-tyrosine in malignant melanoma: cell culture studies and results in patients. | lld:pubmed |
| pubmed-article:9274632 | pubmed:affiliation | Department of Dermatology, University Hospital of Zurich, Switzerland. | lld:pubmed |
| pubmed-article:9274632 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9274632 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9274632 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
