Linked Life Data

9272725

Source:http://linkedlifedata.com/resource/pubmed/id/9272725

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-9-12
pubmed:abstractText
The effects of two cannabinoid receptor agonists, R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4- benzoxazin-yl]-(1-naphthalenyl)-methanone (WIN 55,212-2) and (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydr oxypropyl)-cyclohexanol (CP-55,940), were studied on (i) the vasopressor response elicited in pithed rats by electrical stimulation of the sympathetic outflow and (ii) the release of 3H-noradrenaline and the vasoconstriction elicited in isolated rat tail arteries by transmural electrical stimulation. In pithed rats, the electrical (1 Hz for 10 s) stimulation of the preganglionic sympathetic nerve fibres increased diastolic blood pressure by about 30 mmHg. This neurogenic vasopressor response (which under the conditions of our study was almost exclusively due to the release of catecholamines) was decreased by WIN 55-212,2 and CP-55,940 in a dose-dependent manner (inhibition by WIN 55,212-2 and CP-55,940, 0.1 micromol/kg each, about 25-30%). The inhibition was identical in adrenalectomized rats and in animals with intact adrenals. The inhibitory action of WIN 55,212-2 and CP-55,940 was abolished by a dose of 0.03 micromol/kg of the CB1 receptor antagonist N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazo le-carboxamide (SR 141716), which, by itself, had no effect. WIN 55,212-2, CP-55,940 and SR 141716 failed to affect the vasopressor response to exogenous noradrenaline (1 nmol/kg), which also increased diastolic blood pressure by about 30 mmHg. In isolated rat tail arteries, the electrically (0.4 Hz) evoked tritium overflow and vasoconstriction were not modified by WIN 55,212-2 and CP-55,940 (1 micromol/l each). In conclusion, the neurogenic vasopressor response in the pithed rat can be modulated via cannabinoid CB1 receptors probably located presynaptically on the postganglionic sympathetic nerve fibres innervating resistance vessels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0028-1298
pubmed:author
pubmed:issnType
Print
pubmed:volume
356
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-202
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9272725-Action Potentials, pubmed-meshheading:9272725-Adrenalectomy, pubmed-meshheading:9272725-Animals, pubmed-meshheading:9272725-Benzoxazines, pubmed-meshheading:9272725-Blood Pressure, pubmed-meshheading:9272725-Cyclohexanols, pubmed-meshheading:9272725-Electric Stimulation, pubmed-meshheading:9272725-Heart Rate, pubmed-meshheading:9272725-Male, pubmed-meshheading:9272725-Morpholines, pubmed-meshheading:9272725-Muscle, Smooth, Vascular, pubmed-meshheading:9272725-Muscle Contraction, pubmed-meshheading:9272725-Naphthalenes, pubmed-meshheading:9272725-Norepinephrine, pubmed-meshheading:9272725-Rats, pubmed-meshheading:9272725-Receptors, Cannabinoid, pubmed-meshheading:9272725-Receptors, Drug, pubmed-meshheading:9272725-Vagotomy, pubmed-meshheading:9272725-Vasoconstrictor Agents
pubmed:year
1997
pubmed:articleTitle
Cannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat.
pubmed:affiliation
Zaklad Farmakodynamiki, Akademia Medyczna, Bialystok, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't