Linked Life Data

9272506

Source:http://linkedlifedata.com/resource/pubmed/id/9272506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8 Pt 2
pubmed:dateCreated
1997-10-16
pubmed:abstractText
Aberrations in genes encoding for ion channels have been shown to underlie a number of cardiac arrhythmia syndromes, hitherto classified as idiopathic. These aberrations, inherited and congenital, may lead to dysfunction of channels with resultant abnormal current characteristics. In addition, a variety of stimuli may cause altered expression of these genes. Because prolongation of the action potential (and the QT-interval) is often the result, patients are at risk for the occurrence of arrhythmias based on reentry and the development of abnormal impulse initiation. Molecular dissection of the inherited syndromes has led to rapid progress in our understanding of basic knowledge about ion channel function and its relation to channel structure. This progress is undoubtedly of benefit for the understanding of the repolarization changes in more common conditions and will become of benefit to many more patients who suffer from therapy resistant arrhythmias.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0147-8389
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2048-51
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Ion channels, the QT interval, and arrhythmias.
pubmed:affiliation
Academic Medical Center, The Netherlands.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't