Linked Life Data

9272351

Source:http://linkedlifedata.com/resource/pubmed/id/9272351

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-10-15
pubmed:abstractText
To evaluate the comparability of immunoassays, the Center for Biologics Evaluation and Research organized an international collaborative study in which 33 laboratories participated. For a coded panel of 21 samples, each laboratory measured IgG antibodies to specific proteins of Bordetella pertussis using assay systems currently in place. Analyses were performed to evaluate the assay precision and the quantitative agreement among laboratories. Data from a subset of 12 laboratories are used to illustrate points relevant to the use of immunoassays in seven vaccine efficacy studies. Differences among the laboratories in assay precision for samples with known two-fold differences indicate that serological case definitions must take into consideration the characteristics of the assays and the concentration of antibody in the samples. Assays performed in different laboratories to assess vaccine immunogenicity may generate similar results but critical comparisons will probably require samples to be tested in the same laboratory at the same time.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5149
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-204
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
A comparison of enzyme immunoassays used to measure serum antibodies to components of Bordetella pertussis.
pubmed:affiliation
Center for Biologics Evaluation and Research, Rockville, MD, USA.
pubmed:publicationType
Journal Article, Comparative Study