Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-10-28
|
| pubmed:abstractText |
In a previous study on the effects of TAP1 and TAP2 gene polymorphism in kidney allograft recipients, we found no association between graft outcome and recipient/donor TAP1 and TAP2 allele polymorphism or compatibility, but we observed a surprising increased frequency of the TAP1*0201 allele among kidney recipients. This increase was restricted to patients with glomerulopathy. We now report on a larger cohort of 178 patients with membranous nephropathy who were typed for their HLA-DPB1, -DRB1, -DMA, -DMB, LMP2, LMP, TAP1 and TAP2 genes compared with 100 random ethnically matched and healthy unrelated individuals used as controls. The results show a significant increased frequency of two markers in membranous nephropathy patients as compared with controls: firstly the previously recognized increase in HLA-DR3 (59% vs 18%: Pc < 1 x 10(-9), RR = 6.6), secondly a new association with two TAP1 amino acid variants displaying respectively a valine in amino acid position 333 (TAP1-Val-333) and consequently a glycine in position 637 (TAP1Gly-637) due to its strong linkage disequilibrium with Val-333. No linkage disequilibrium was found between TAP1-Val-333 and HLA-DR3. Moreover, we also noticed a decrease of the DMA*0102 phenotype in membranous nephropathy patients. The other HLA-DPB, -DMB, LMP2, LMP7 and TAP2 phenotype frequencies were roughly similar between patients and controls. These results show that the TAP1-Val-333 like HLA-DR3 phenotype is positively associated with membranous nephropathy and that these two risk factors are not cumulative in membranous nephropathy pathophysiology.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/H2-M antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-D Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DM antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/TAP1 protein, human
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0001-2815
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
50
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
164-9
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9271826-ATP-Binding Cassette Transporters,
pubmed-meshheading:9271826-Adolescent,
pubmed-meshheading:9271826-Adult,
pubmed-meshheading:9271826-Aged,
pubmed-meshheading:9271826-Aged, 80 and over,
pubmed-meshheading:9271826-Biological Markers,
pubmed-meshheading:9271826-DNA,
pubmed-meshheading:9271826-DNA Primers,
pubmed-meshheading:9271826-Female,
pubmed-meshheading:9271826-Gene Frequency,
pubmed-meshheading:9271826-Genes, MHC Class II,
pubmed-meshheading:9271826-Genetic Linkage,
pubmed-meshheading:9271826-Glomerulonephritis, Membranous,
pubmed-meshheading:9271826-HLA-D Antigens,
pubmed-meshheading:9271826-Histocompatibility Antigens Class II,
pubmed-meshheading:9271826-Humans,
pubmed-meshheading:9271826-Major Histocompatibility Complex,
pubmed-meshheading:9271826-Male,
pubmed-meshheading:9271826-Middle Aged,
pubmed-meshheading:9271826-Polymorphism, Genetic
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Idiopathic and secondary membranous nephropathy and polymorphism at TAP1 and HLA-DMA loci.
|
| pubmed:affiliation |
Etablissement de Transfusion Sanguine 44-85, Laboratoire HLA, Nantes, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|