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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-9-15
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pubmed:abstractText |
The composition and physical state of membrane lipids determine the dynamic nature of membranes, which in turn, could directly be linked to the activity of various membrane-associated cellular functions. To better understand the molecular basis of different membrane-related phenomena we established a novel strategy to alter unsaturation of mammalian cell membranes with an identical genetic background. We transfected L929 mouse fibroblastoid cells with DNA constructs containing the Delta9-fatty acid desaturase gene (Ole1) of S. cerevisiae under the control of desaturase promoters derived either from wild type or mutant strains of the dimorphic fungus H. capsulatum.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
237
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
362-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9268717-Animals,
pubmed-meshheading:9268717-Cell Line, Transformed,
pubmed-meshheading:9268717-DNA, Fungal,
pubmed-meshheading:9268717-Fatty Acid Desaturases,
pubmed-meshheading:9268717-Lipid Metabolism,
pubmed-meshheading:9268717-Membrane Fluidity,
pubmed-meshheading:9268717-Mice,
pubmed-meshheading:9268717-Saccharomyces cerevisiae,
pubmed-meshheading:9268717-Transformation, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Modulation of lipid unsaturation and membrane fluid state in mammalian cells by stable transformation with the delta9-desaturase gene of Saccharomyces cerevisiae.
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pubmed:affiliation |
Institute of Biochemistry, BRC, Szeged, Hungary.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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