Linked Life Data

9267045

Source:http://linkedlifedata.com/resource/pubmed/id/9267045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-9-9
pubmed:abstractText
The brain glucose transporter GLUT1 is a transmembrane glycoprotein belonging to the glucose carrier family comprising five isoforms characterized by different functional properties and tissue specificity. Biochemical and immunohistochemical analyses have demonstrated that GLUT isoform 1 is localised within the brain microvascular endothelium, where it controls glucose uptake through the blood-brain barrier (BBB). In this study the expression of GLUT1 was analysed by means of light and electron immunocytochemistry in the adult human cerebellar cortex. The glucose transporter is strongly expressed in cerebellum microvessels, and is localised not only within endothelial cells but also in microvascular pericytes. Moreover, some glial expression of GLUT1 was observed in the neutrophil and in perivascular glial sheaths. The observations demonstrate that different cellular types are involved in the control of brain glucose homeostasis by GLUT1 expression at the BBB site, and support the postulated highly specialised role of brain microvascular pericytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1122-9497
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-70
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Glucose transporter GLUT1 in human brain microvessels revealed by ultrastructural immunocytochemistry.
pubmed:affiliation
Institute of Human Anatomy, Histology and Embryology, University Medical School, Bari, Italy.
pubmed:publicationType
Journal Article