Linked Life Data

9266781

Source:http://linkedlifedata.com/resource/pubmed/id/9266781

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-9-11
pubmed:abstractText
Patients with heart failure and left ventricular systolic dysfunction exhibit increased adrenergic activity but blunted adrenergic responsiveness. We studied patients enrolled in the Studies of Left Ventricular Dysfunction, examining exercise responses of heart rate (HR) and plasma norepinephrine (PNE). Eighty-seven patients were studied before randomization; 65 of these were examined 1 year after randomization to placebo or enalapril. Compared with prevention trial (asymptomatic) patients, patients in the treatment trial (symptomatic) had higher resting HR and PNE levels and less increase in HR with a greater increase in PNE with exercise. Acute administration of enalapril increased the resting HR in patients in the prevention trial only but had no significant effect on PNE. After 1 year of therapy, patients in the prevention trial exhibited no change. Within the treatment trial, the placebo group displayed both a higher peak PNE and increase in PNE with exercise than did the enalapril group, whose HR response was maintained in spite of a reduction of exercise PNE. We conclude that (1) compared with asymptomatic patients, symptomatic patients with reduced left ventricular ejection fraction manifest greater resting and exercise adrenergic activity, with blunted HR response; and (2) in symptomatic patients, 1 year of enalapril treatment effected an augmented HR response to adrenergic stimulation, supporting an interaction between the renin/angiotensin and adrenergic nervous systems. Normalization of adrenergic tone and response likely contributes to the benefits of long-term angiotensin-converting enzyme inhibitor therapy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-8703
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-43
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:9266781-Aged, pubmed-meshheading:9266781-Angiotensin-Converting Enzyme Inhibitors, pubmed-meshheading:9266781-Blood Pressure, pubmed-meshheading:9266781-Cardiac Output, Low, pubmed-meshheading:9266781-Enalapril, pubmed-meshheading:9266781-Exercise Test, pubmed-meshheading:9266781-Female, pubmed-meshheading:9266781-Heart Rate, pubmed-meshheading:9266781-Humans, pubmed-meshheading:9266781-Longitudinal Studies, pubmed-meshheading:9266781-Male, pubmed-meshheading:9266781-Middle Aged, pubmed-meshheading:9266781-Norepinephrine, pubmed-meshheading:9266781-Physical Exertion, pubmed-meshheading:9266781-Placebos, pubmed-meshheading:9266781-Renin-Angiotensin System, pubmed-meshheading:9266781-Rest, pubmed-meshheading:9266781-Stroke Volume, pubmed-meshheading:9266781-Sympathetic Nervous System, pubmed-meshheading:9266781-Sympathomimetics, pubmed-meshheading:9266781-Systole, pubmed-meshheading:9266781-Time Factors, pubmed-meshheading:9266781-Ventricular Dysfunction, Left
pubmed:year
1997
pubmed:articleTitle
Acute and long-term effects of the angiotensin-converting enzyme inhibitor, enalapril, on adrenergic activity and sensitivity during exercise in patients with left ventricular systolic dysfunction.
pubmed:affiliation
Department of Medicine, Tufts University, New England Medical Center, Boston, Mass. 02111, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial