Linked Life Data

9261895

Source:http://linkedlifedata.com/resource/pubmed/id/9261895

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-9-22
pubmed:abstractText
Chronic hepatitis develops in at least half of the patients with acute hepatitis C. Although there is currently no effective therapy for chronic hepatitis C (CHC), it is reported that Interferon-alpha (IFN alpha) has some beneficial effects. It has been suggested that changes in the oxidant-antioxidant balance may take decisive role in the progression of liver damage in viral hepatitis and IFN alpha might be effective in the treatment of liver damage by improving the antioxidant system. In the present study, when the patients with chronic active hepatitis-C (CAH-C) were compared to controls, serum thiobarbituric acid reactive substance (TBARS) levels and glutathione peroxidase (GPx) activity as well as transaminase activities were increased, but total sulfhydryl (t-SH) contents were decreased Following IFN alpha treatment three times a week for a period of 6 months, it has been observed that elevated TBARS levels and GPx activity were decreased and reduced t-SH contents were increased significantly in patients with chronic active hepatitis-C (CAH-C). According to our results, these findings suggests that oxidative stress may play an important role in HCV induced liver injury and IFN alpha may be useful in treatment by reducing the oxidative stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1078-0297
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
357-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
The effects of interferon-alpha on serum lipid peroxidation and total thiol content in patients with chronic active hepatitis-C.
pubmed:affiliation
Department of Biochemistry, Ystanbul Faculty of Medicine, University of Ystanbul, Turkey.
pubmed:publicationType
Journal Article, Comparative Study