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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1998-1-8
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pubmed:abstractText |
cAMP-dependent protein kinase (cAPK), a ubiquitous protein in eukaryotic cells, is one of the simplest members of the protein kinase family. It was the first protein kinase to be crystallized and continues to serve as a biochemical and structural prototype for this family of enzymes. To further understand the conformational changes that occur in different liganded and unliganded states of cAPK, the catalytic subunit of cAPK was crystallized in the absence of peptide inhibitor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
921-35
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9261084-Adenosine,
pubmed-meshheading:9261084-Animals,
pubmed-meshheading:9261084-Binding Sites,
pubmed-meshheading:9261084-Catalysis,
pubmed-meshheading:9261084-Computer Graphics,
pubmed-meshheading:9261084-Crystallization,
pubmed-meshheading:9261084-Crystallography, X-Ray,
pubmed-meshheading:9261084-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:9261084-Ligands,
pubmed-meshheading:9261084-Mice,
pubmed-meshheading:9261084-Models, Molecular,
pubmed-meshheading:9261084-Molecular Structure,
pubmed-meshheading:9261084-Nucleosides,
pubmed-meshheading:9261084-Peptides,
pubmed-meshheading:9261084-Protein Conformation,
pubmed-meshheading:9261084-Protein Structure, Tertiary,
pubmed-meshheading:9261084-Recombinant Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility.
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pubmed:affiliation |
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093-0359, USA. Narendra@chem.ucsd.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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