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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1997-9-22
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pubmed:abstractText |
DNA damage in mammalian cells stabilizes the p53 protein which then functions as a cell cycle checkpoint by leading to growth arrest or apoptosis. p53 is a transcription factor and positively regulates the expression of the p21/WAF-1 gene and the mdm2 gene. After high-dose UV irradiation, p53 increases the expression of the p21/WAF-1 gene immediately (2 to 5 hours after irradiation) while the induction of the mdm2 gene is delayed (8 to 12 hours after irradiation). Experiments presented here explore this differential expression of two different p53-regulated genes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-1423616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-1535557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-1600943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-1614537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-1933891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-2026149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-3474784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-7477326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-7477327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-7791903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-7791904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-7949188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-7958853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8146175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8183579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8219216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8242748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8242752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8247544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8265599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8319905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8324731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8387391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8416741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8417333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8504413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8529093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8628312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9260156-8956998
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Mdm2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mdm2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1076-1551
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
441-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9260156-Animals,
pubmed-meshheading:9260156-Cell Line,
pubmed-meshheading:9260156-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:9260156-Cyclins,
pubmed-meshheading:9260156-Dose-Response Relationship, Radiation,
pubmed-meshheading:9260156-Down-Regulation,
pubmed-meshheading:9260156-Fibroblasts,
pubmed-meshheading:9260156-Gene Expression Regulation,
pubmed-meshheading:9260156-Mice,
pubmed-meshheading:9260156-Nuclear Proteins,
pubmed-meshheading:9260156-Proto-Oncogene Proteins,
pubmed-meshheading:9260156-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:9260156-Proto-Oncogenes,
pubmed-meshheading:9260156-RNA, Messenger,
pubmed-meshheading:9260156-Rats,
pubmed-meshheading:9260156-Transcription, Genetic,
pubmed-meshheading:9260156-Tumor Suppressor Protein p53,
pubmed-meshheading:9260156-Ultraviolet Rays
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pubmed:year |
1997
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pubmed:articleTitle |
Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.
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pubmed:affiliation |
Department of Molecular Biology, Princeton University, NJ 08544-1014, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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