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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-9-3
|
| pubmed:abstractText |
Many patients with exocrine pancreatic cancer develop diabetes mellitus due to insulin resistance. This may relate to concurrent over-production of islet amyloid polypeptide (IAPP) by the pancreatic beta cells. We investigated the effects of pancreatic cancer on circulating IAPP and glucose homeostasis in azaserine-treated rats (developing acinar pancreatic tumours) and BOP-treated hamsters (developing ductular pancreatic tumours). Glucose, insulin and IAPP levels in plasma were neither affected in azaserine-only treated rats nor in animals with enhanced carcinogenesis after chronic caerulein treatment. Azaserine-treated rats on a high-fat diet had decreased insulin levels and enhanced IAPP/insulin ratios in plasma, without hyperglycaemia. All BOP-treated hamsters showed pancreatic carcinogenesis at 6 months post-treatment. Supranormal plasma glucose levels in animals on a low-fat diet were the only change observed. After a second 6-month period, subnormal plasma glucose levels, at least 4-fold decreased plasma insulin and up to 2-fold decreased plasma IAPP levels were present in all hamsters. Remarkably, both in azaserine-treated rats on high-fat and in BOP-treated hamsters, decreased insulin levels and elevated IAPP/insulin ratios are not associated with hyperglycaemia. In contrast to humans with pancreatic cancer, IAPP over-production and hyperglycaemia do not develop in rats and hamsters with (pre-)neoplastic pancreatic lesions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Islet Amyloid Polypeptide
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
7
|
| pubmed:volume |
72
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
637-41
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9259404-Amyloid,
pubmed-meshheading:9259404-Animals,
pubmed-meshheading:9259404-Blood Glucose,
pubmed-meshheading:9259404-Body Weight,
pubmed-meshheading:9259404-Carcinogens,
pubmed-meshheading:9259404-Cricetinae,
pubmed-meshheading:9259404-Dietary Fats,
pubmed-meshheading:9259404-Disease Models, Animal,
pubmed-meshheading:9259404-Homeostasis,
pubmed-meshheading:9259404-Hyperglycemia,
pubmed-meshheading:9259404-Insulin,
pubmed-meshheading:9259404-Islet Amyloid Polypeptide,
pubmed-meshheading:9259404-Male,
pubmed-meshheading:9259404-Mesocricetus,
pubmed-meshheading:9259404-Organ Size,
pubmed-meshheading:9259404-Pancreas,
pubmed-meshheading:9259404-Pancreatic Neoplasms,
pubmed-meshheading:9259404-Precancerous Conditions,
pubmed-meshheading:9259404-Rats,
pubmed-meshheading:9259404-Rats, Wistar
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Pancreatic cancer in rats and hamsters does not induce IAPP-related hyperglycaemia.
|
| pubmed:affiliation |
Department of Internal Medicine, University Hospital Utrecht, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|