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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1997-12-1
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pubmed:abstractText |
A technique has been developed for preparing the mouse temporal bone for histopathological examination: first, as a whole mount to detect any gross malformations of the bony or membranous labyrinths; second, in dissected segments to localize damage in the different sensory organs and to quantify sensory- and supporting-cell losses; and finally, in semi-thick and thin sections to identify and characterize subcellular pathology. Examples are given of the successful application of this technique to mice with very different inner-ear problems, including those with an abnormally short cochlear spiral, a defective lateral semicircular canal, abnormal otoliths over the saccular macula, an increased susceptibility to noise damage and those which lack fibroblast growth factor receptor 3.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0378-5955
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-45
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9259234-Animals,
pubmed-meshheading:9259234-Cochlea,
pubmed-meshheading:9259234-Hair Cells, Auditory, Inner,
pubmed-meshheading:9259234-Hair Cells, Auditory, Outer,
pubmed-meshheading:9259234-Mice,
pubmed-meshheading:9259234-Microscopy, Electron,
pubmed-meshheading:9259234-Microscopy, Phase-Contrast,
pubmed-meshheading:9259234-Mutation,
pubmed-meshheading:9259234-Nerve Fibers,
pubmed-meshheading:9259234-Plastic Embedding,
pubmed-meshheading:9259234-Saccule and Utricle,
pubmed-meshheading:9259234-Spiral Ganglion,
pubmed-meshheading:9259234-Temporal Bone,
pubmed-meshheading:9259234-Tissue Fixation
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pubmed:year |
1997
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pubmed:articleTitle |
Processing and analyzing the mouse temporal bone to identify gross, cellular and subcellular pathology.
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pubmed:affiliation |
Washington University School of Medicine, Department of Otolaryngology, St. Louis, MO 63110, USA. bohne_b@kids.wustl.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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