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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-9-30
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pubmed:abstractText |
Adenoviral gene transfer and killing efficiency using the thymidine kinase (TK)/ganciclovir (GCV) mechanism was evaluated in human cancer cells occurring as central nervous system tumors. The effectiveness of this approach was tested in vitro and in experimental models for brain tumor and leptomeningeal metastases in rats in vivo. Recombinant adenoviruses with different promoters were compared.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0148-396X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
442-51; discussion 451-2
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9257313-Adenoviridae,
pubmed-meshheading:9257313-Animals,
pubmed-meshheading:9257313-Antiviral Agents,
pubmed-meshheading:9257313-Arachnoid,
pubmed-meshheading:9257313-Brain Neoplasms,
pubmed-meshheading:9257313-Central Nervous System Neoplasms,
pubmed-meshheading:9257313-Cytomegalovirus,
pubmed-meshheading:9257313-Ganciclovir,
pubmed-meshheading:9257313-Gene Dosage,
pubmed-meshheading:9257313-Gene Therapy,
pubmed-meshheading:9257313-Humans,
pubmed-meshheading:9257313-Meningeal Neoplasms,
pubmed-meshheading:9257313-Pia Mater,
pubmed-meshheading:9257313-Promoter Regions, Genetic,
pubmed-meshheading:9257313-Rats,
pubmed-meshheading:9257313-Recombination, Genetic,
pubmed-meshheading:9257313-Simplexvirus,
pubmed-meshheading:9257313-Survival Analysis,
pubmed-meshheading:9257313-Thymidine Kinase,
pubmed-meshheading:9257313-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Preclinical testing of recombinant adenoviral herpes simplex virus-thymidine kinase gene therapy for central nervous system malignancies.
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pubmed:affiliation |
Department of Neurosurgery, University Hospital Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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