|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0031715,
umls-concept:C0033684,
umls-concept:C0037657,
umls-concept:C0220611,
umls-concept:C0332307,
umls-concept:C0449432,
umls-concept:C1179435,
umls-concept:C1514762,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1564904,
umls-concept:C1705248,
umls-concept:C2611812
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1997-8-29
|
|
pubmed:abstractText |
Rhabdomyosarcomas (RMS) are heterogeneous in their clinical presentation, histology, and cytogenetics. The growth of some RMS cells has been found to be regulated by the tyrosine kinase insulin-like growth factor (IGF) type I receptor. However, RMS cells exhibit variable sensitivity to inhibitors of tyrosine kinases and IGF receptors. Collectively, these heterogeneous features suggest that differences exist in the growth regulatory pathways of RMS. The objective of this study is to identify active tyrosine kinase signal transduction pathways in embryonal and alveolar RMS cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Catenins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/delta catenin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1077-4114
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
319-26
|
|
pubmed:dateRevised |
2011-10-6
|
|
pubmed:meshHeading |
pubmed-meshheading:9256831-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:9256831-Adolescent,
pubmed-meshheading:9256831-Cadherins,
pubmed-meshheading:9256831-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9256831-Catenins,
pubmed-meshheading:9256831-Cell Adhesion Molecules,
pubmed-meshheading:9256831-Child,
pubmed-meshheading:9256831-Child, Preschool,
pubmed-meshheading:9256831-Enzyme Activation,
pubmed-meshheading:9256831-Female,
pubmed-meshheading:9256831-GRB2 Adaptor Protein,
pubmed-meshheading:9256831-Humans,
pubmed-meshheading:9256831-Infant,
pubmed-meshheading:9256831-Neoplasm Proteins,
pubmed-meshheading:9256831-Phosphoproteins,
pubmed-meshheading:9256831-Phosphorylation,
pubmed-meshheading:9256831-Phosphotyrosine,
pubmed-meshheading:9256831-Protein-Tyrosine Kinases,
pubmed-meshheading:9256831-Proteins,
pubmed-meshheading:9256831-Receptor, IGF Type 1,
pubmed-meshheading:9256831-Rhabdomyosarcoma,
pubmed-meshheading:9256831-Signal Transduction,
pubmed-meshheading:9256831-Tumor Cells, Cultured,
pubmed-meshheading:9256831-Tyrosine
|
|
pubmed:articleTitle |
Phosphotyrosyl proteins in childhood rhabdomyosarcomas: phosphorylation of catenins and components of the insulin-like growth factor type I receptor signaling cascade.
|
|
pubmed:affiliation |
Department of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN 55905, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
