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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
7
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pubmed:dateCreated |
1997-12-8
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pubmed:abstractText |
The effect of indole alkaloids from Sickingia williamsii Standl. (Rubiaceae) on the effects of morphine withdrawal have been examined in-vitro. All the indole alkaloids isolated from S. williamsii (10(-4), 5 x 10(-5) and 10(-5) M) significantly and in a concentration-dependent manner reduced the effects of morphine withdrawal on the guinea-pig ileum. The results suggest that these alkaloids might be potential anti-addictive agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-3573
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
712-4
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9255716-Acetylcholine,
pubmed-meshheading:9255716-Alkaloids,
pubmed-meshheading:9255716-Animals,
pubmed-meshheading:9255716-Disease Models, Animal,
pubmed-meshheading:9255716-Dose-Response Relationship, Drug,
pubmed-meshheading:9255716-Electric Stimulation,
pubmed-meshheading:9255716-Guinea Pigs,
pubmed-meshheading:9255716-Ileum,
pubmed-meshheading:9255716-Indoles,
pubmed-meshheading:9255716-Male,
pubmed-meshheading:9255716-Morphine,
pubmed-meshheading:9255716-Morphine Dependence,
pubmed-meshheading:9255716-Naloxone,
pubmed-meshheading:9255716-Narcotic Antagonists,
pubmed-meshheading:9255716-Narcotics,
pubmed-meshheading:9255716-Rubiaceae,
pubmed-meshheading:9255716-Substance Withdrawal Syndrome
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pubmed:year |
1997
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pubmed:articleTitle |
Indole alkaloids from Sickingia williamsii reduce the in-vitro effects of morphine withdrawal in the guinea-pig.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Salerno, Italy.
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pubmed:publicationType |
Journal Article
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