Linked Life Data

9254857

Source:http://linkedlifedata.com/resource/pubmed/id/9254857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-9-8
pubmed:abstractText
Two KM alleles occur in 1075 South Amerinds of 14 tribes in approximately balanced and uniform frequency. However, the number of heterozygotes is 12.7% greater than expected by frequency analysis and 16.5% greater by segregation analysis. This excess is evident in children 0-4 years of age and may reflect either prenatal or early childhood selection. The frequencies of GM haplotypes were different, and quite uniformly so, in diverse tribes. Most GM heterozygotes can only be distinguished from GM 1,2,17 21 homozygotes by DNA or family relationship. No deficit of GM homozygotes was observed in 119 children in whom heterozygosis was determined by family. Thus, the KM polymorphism, like HLA, may be maintained by preferential survival of heterozygotes, but GM probably depends on another mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0340-6717
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
240-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Evidence for balancing of KM, but not GM, alleles by heterotic advantage in South Amerinds.
pubmed:affiliation
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06529-8034, USA.
pubmed:publicationType
Journal Article