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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4A
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pubmed:dateCreated |
1997-9-3
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pubmed:abstractText |
We have demonstrated that anticancer drugs at cytostatic concentrations enhance the expression and function of epidermal growth factor (EGF-R) and transferrin (TRF-R) receptors on human tumor cells. We hypothesized that these effects could represent a protective response of tumor cells to sublethal antiproliferative stimuli which could lead to enhanced growth potential. 72 hours exposure of human melanoma GLL-19 cells to 1,000 nM ara-C induced growth inhibition and increased the number of EGF-R, TRF-R and nerve growth factor receptor (NGF-R) on cell surface. Enhanced expression of beta 3 integrins CD49a, CD49c and CD49e, av integrin CD51, beta 3 integrin CD61, CD58/LFA3 and collagen IV and laminin was also detected in ara-C-treated GLL-19 cells. These changes at the tumor cell surface were paralleled by increased in vitro adhesion, invasive potential and clonogenic growth in soft agar and in vivo tumor formation. A more aggressive tumor cell phenotype is induced in human melanoma cells after transient exposure to cytostatic concentrations of ara-C.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytarabine,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transferrin,
http://linkedlifedata.com/resource/pubmed/chemical/Transferrin
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
pubmed-author:ArraCC,
pubmed-author:BiancoA RAR,
pubmed-author:CaragliaMM,
pubmed-author:FabbrociniAA,
pubmed-author:FerrariVV,
pubmed-author:ImprotaSS,
pubmed-author:LeardiA IAI,
pubmed-author:PerisSS,
pubmed-author:PintoAA,
pubmed-author:RicciardiBB,
pubmed-author:TagliaferroVV
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2369-75
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9252649-Animals,
pubmed-meshheading:9252649-Cell Adhesion,
pubmed-meshheading:9252649-Cell Cycle,
pubmed-meshheading:9252649-Cell Division,
pubmed-meshheading:9252649-Cytarabine,
pubmed-meshheading:9252649-Drug Administration Schedule,
pubmed-meshheading:9252649-Epidermal Growth Factor,
pubmed-meshheading:9252649-Humans,
pubmed-meshheading:9252649-Integrins,
pubmed-meshheading:9252649-Melanoma,
pubmed-meshheading:9252649-Mice,
pubmed-meshheading:9252649-Mice, Nude,
pubmed-meshheading:9252649-Neoplasm Invasiveness,
pubmed-meshheading:9252649-Neoplasms, Experimental,
pubmed-meshheading:9252649-Nerve Growth Factors,
pubmed-meshheading:9252649-Receptor, Epidermal Growth Factor,
pubmed-meshheading:9252649-Receptors, Nerve Growth Factor,
pubmed-meshheading:9252649-Receptors, Transferrin,
pubmed-meshheading:9252649-Transferrin,
pubmed-meshheading:9252649-Tumor Cells, Cultured,
pubmed-meshheading:9252649-Up-Regulation
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pubmed:articleTitle |
Transient exposure to cytarabine increases peptide growth factor receptor expression and tumorigenicity of melanoma cells.
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pubmed:affiliation |
Cattedra di Oncologia Medica, Università Federico II di Napoli, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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