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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0017262,
umls-concept:C0018894,
umls-concept:C0021013,
umls-concept:C0026809,
umls-concept:C0185117,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
1980-2-26
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pubmed:abstractText |
The X-linked CBA/N defect in B cell function precludes an antibody response to phosphorylcholine (PC). Accordingly, (CBA/N X BALB/c)F1 male mice are unresponsive to PC and lack circulating immunoglobulin bearing the T15 idiotype characteristic of BALB/C anti-PC antibody. In contrast, (CBA/N X BALB/c)F1 female mice respond to PC and greater than 80% of the anti-PC antibody is T15+. No T-cell abnormalities are known to be associated with the CBA/N mutation. These experiments compared the ability of helper T cells from either (CBA/N X BALB/c)F1 male (T15-) or F1 female (T15+) mice to help F1 female B cells respond to PC and to influence the level of T15 expression. The results indicate that although F1 male T cells collaborated with F1 female B cells just as efficiently as F1 female T cells for the total anti-PC response, the percentage of T15 expression induced by F1 male T cells fell dramatically. The (CBA/N X BALB/c)F1 male thus appear to lack a helper T-cell subset required for dominant idiotype production. This helper T cell defect could be repaired by adding F1 female T cells primed to a second carrier to F1 male T cells and restimulating the cell mixture with PC coupled to the antigen used to prime the F1 male cells plus free second carrier. This result implies that conventional helper T cells derived from the F1 male donor can collaborate with a distinct helper T-cell subset from the F1 female donor which recognizes both carrier and idiotype to induce an anti-PC antibody response dominated by the T15 clonotype.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-1079035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-1085324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-1089726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-1090698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-11100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-14978857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-17815805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-302313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-308883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-309912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-310860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-322367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-365546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-4126287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-4150447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-415110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-5059886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-52924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-73181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-80953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-83234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/92522-83698
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1399-409
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:92522-Animals,
pubmed-meshheading:92522-Antibody Formation,
pubmed-meshheading:92522-Antibody Specificity,
pubmed-meshheading:92522-B-Lymphocytes,
pubmed-meshheading:92522-Carrier Proteins,
pubmed-meshheading:92522-Epitopes,
pubmed-meshheading:92522-Female,
pubmed-meshheading:92522-Genetic Linkage,
pubmed-meshheading:92522-Immunoglobulin Idiotypes,
pubmed-meshheading:92522-Lymphocyte Cooperation,
pubmed-meshheading:92522-Male,
pubmed-meshheading:92522-Mice,
pubmed-meshheading:92522-Mice, Inbred Strains,
pubmed-meshheading:92522-Phosphorylcholine,
pubmed-meshheading:92522-Rabbits,
pubmed-meshheading:92522-T-Lymphocytes,
pubmed-meshheading:92522-X Chromosome
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pubmed:year |
1979
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pubmed:articleTitle |
Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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