Linked Life Data

9250885

Source:http://linkedlifedata.com/resource/pubmed/id/9250885

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1997-9-25
pubmed:abstractText
The disinfectant activity of ozone is well recognized and ozone is used worldwide for sterilization of water. The use of ozone as a complementary medical approach is less known, because it has mostly been used in an empirical fashion without a rational basis and appropriate controls. In spite of this drawback, the use of judicious and standardized ozone dosages can elicit the formation of ROS acting as natural physiological activators of several biological functions. There is now a reasonable understanding of a few mechanisms of action and, using classical pharmacological concepts, it appears possible to formulate a rationale for optimizing clinical applications. A further exciting development is that ozone, being an oxidizer, can upregulate the intracellular anti-oxidant enzymes eventually inhibiting the constant, life-long oxidative stress responsible for degenerative diseases and aging. Among various routes for the administration of ozone, the autohemotransfusion procedure, consisting in exposing blood to ozone, i.e. to a calculated and brief oxidative stress, appears safe, simple, inexpensive and amenable to be adjusted to different pathological states It is hoped that this review will help to dispel prejudices, to clarify that ozone toxicity can be tamed, to show that ozone can act as a bioregulator and to encourage controlled clinical investigations to evaluate definitely the validity of ozonetherapy.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0393-974X
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Ozone as a bioregulator. Pharmacology and toxicology of ozonetherapy today.
pubmed:affiliation
Institute of General Physiology, University of Siena, Italy.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't