Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1997-9-12
|
| pubmed:abstractText |
New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0163-3864
|
| pubmed:author |
pubmed-author:BoydM RMR,
pubmed-author:BringmannGG,
pubmed-author:CardellinaJ HJH2nd,
pubmed-author:DayJ BJB,
pubmed-author:FrançoisGG,
pubmed-author:GulakowskiR JRJ,
pubmed-author:GuldenK PKP,
pubmed-author:HallockY FYF,
pubmed-author:ManfrediK PKP,
pubmed-author:McMahonJ BJB,
pubmed-author:SchäfferMM,
pubmed-author:StahlMM
|
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
677-83
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1997
|
| pubmed:articleTitle |
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
|
| pubmed:affiliation |
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|