Linked Life Data

9249583

Source:http://linkedlifedata.com/resource/pubmed/id/9249583

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 2
pubmed:dateCreated
1997-9-3
pubmed:abstractText
Because dissection of the common hepatic vagus branch attenuated the feeding response to intraperitoneal injection of mercaptoacetate (MA), an inhibitor of fatty acid oxidation, in rats fed a fat-enriched diet (18% fat), the effect of MA on the discharge rate in afferents of the common hepatic vagus branch was investigated. Intraportal infusion of the Na salt of MA (200, 400, and 800 mumol/kg) in rats adapted to the 18% fat diet dose dependently increased the discharge rate in afferents of the common hepatic vagus branch, whereas NaCl and the Na salt of the structurally related compound 2-mercaptopropionate had no effect. The lowest dose of MA yielding a significant increase in the discharge rate was 400 mumol/kg. This agrees with the dose dependence of the feeding response to MA. These findings are consistent with the notion that hepatic fatty acid oxidation controls food intake by modulating the discharge rate of vagal afferents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
273
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R442-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Intraportal mercaptoacetate infusion increases afferent activity in the common hepatic vagus branch of the rat.
pubmed:affiliation
Institute of Veterinary Physiology, University of Zurich, Switzerland.
pubmed:publicationType
Journal Article