Linked Life Data

9249543

Source:http://linkedlifedata.com/resource/pubmed/id/9249543

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 2
pubmed:dateCreated
1997-9-3
pubmed:abstractText
Arginine vasopressin (AVP) may act as a neurotransmitter or neuromodulator in the solitary tract nucleus (NTS). To determine whether AVP influences the activity of NTS neurons receiving cardiovascular afferent input, we used single-unit extracellular recording combined with local microinjection to test the effects of AVP and V1-receptor antagonists (antAVP) on spontaneously active NTS neurons in anesthetized rats. Phenylephrine-induced increases in arterial pressure were used to identify neurons receiving baroreceptor input. Phenylbiguanide was used to stimulate chemosensitive cardiopulmonary receptors. AVP excited 31 of 81 NTS neurons tested and inhibited 15 of 81 neurons. AntAVP had independent effects on NTS neurons: in addition to blocking the effects of AVP, antAVP inhibited 26 of 72 neurons but excited only 13. Eighty-two percent of NTS neurons receiving excitatory or inhibitory baroreceptor inputs responded to AVP; 61% of these were excited by AVP. Fifty-eight percent of neurons receiving cardiopulmonary receptor input responded to AVP. These results suggest that AVP in rat NTS has a tonic, predominantly excitatory influence on a significant proportion of baroreceptor-related neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
273
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R143-52
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Vasopressin and V1-receptor antagonists modulate the activity of NTS neurons receiving baroreceptor input.
pubmed:affiliation
Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242, USA. ahegarty@blue.weeg.uiowa.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't